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Posted by kallemroden on June 12, 2020 at 2:40 AM Comments comments (20)


Infectious arthritis caused by non-gonococcal bacteria can lead to irreversible destruction of the cartilage tissue of the joint within a few hours or days..

Infectious arthritis caused by gonococcal bacteria usually does not cause permanent damage to the joints.

In patients with rheumatoid arthritis, a complete recovery of the infected joint is usually not observed, and the frequency of deaths is increased.

Pharmacological effect

Many gram-positive and gram-negative bacteria are sensitive to the action of Augmentin, among which:


  • E. coli, including those producing beta-lactamase;
  • enterobacteria;
  • Klebsiella;
  • Staphylococcus aureus, including beta-lactamase producing strains;
  • streptococcus;
  • Neisseria, the causative agent of gonorrhea;
  • moraxella;
  • Proteus.


Separately, we note that methicillin-resistant strains of Staphylococcus aureus, which cause dangerous nosocomial infections, are insensitive to Augmentin.

The mechanism of action of Amoxicillin is extremely simple. The antibiotic blocks the synthesis of the cell wall of a sensitive microorganism and thus has a bactericidal effect. The pharmacological effect in Augmentin has only one active substance of the drug - amoxicillin. Clavulanic acid has no antibacterial effect.


Exceeding the dose of Augmentin is accompanied by:


  • the development of disorders of the digestive tract;
  • violation of the water-salt balance;
  • crystalluria;
  • renal failure;
  • precipitation of amoxicillin in the urinary catheter.


When such symptoms appear, the patient is shown symptomatic therapy, including, among other things, the correction of the disturbed water-salt balance. The hemodialysis procedure also contributes to the removal of Augmentin from the circulatory system..


If you exceed the dose of the suspension prescribed by the doctor, this can disrupt the digestive system of the child and affect the water-electrolyte balance in his body. It is also possible the formation of crystals in the urine, which is why an overdose can provoke kidney failure. If the child has sick kidneys, then overdosing can cause seizures.

Admission Rules

When giving medication to a child, parents need to remember:


  1. Antibiotic should not be taken for less than 5 days.
  2. Do not drink the medicine for a child longer than 2 weeks without reviewing the clinical case.
  3. Before giving the drug to a child under 2 years of age, the suspension can be diluted with water 1: 1.
  4. So that the medication does not lose its bactericidal effect, it must be kept at a temperature of up to 25 degrees for 24 months. After dissolution, it must be stored at t from 2 to 8 degrees. Suitable suspension only a week.
  5. Probenecid can increase the content of amoxicillin in the blood, so it is not recommended to take it during treatment with Augmentin.
  6. With the appointment of allopurinol simultaneously with antibiotic therapy, the risk of skin allergic reactions increases.
  7. Augmentin may increase the harmful effects of methotrexate.
  8. An antibiotic may decrease estrogen adsorption, which may decrease the effectiveness of hormonal birth control pills..
  9. Against the background of antibiotic therapy, a dosage adjustment of oral coagulants may be necessary.
  10. If anaphylaxis has begun due to the administration of the suspension, then epinephrine should be administered to the child as soon as possible. If necessary, the doctor may prescribe oxygen therapy, the introduction of glucocorticoids into a vein. May require airway restoration.
  11. During long-term antibiotic therapy, the condition of the liver and kidneys should be checked periodically, a blood test.
  12. If severe diarrhea with cramping in the abdomen started due to taking the medication, then this may be a sign of pseudomembranous colitis. Therefore, when these symptoms appear, you need to interrupt treatment and consult a doctor.
  13. When taking the antibiotic, you should drink enough fluid to prevent crystalluria.
  14. To prevent discolouration of tooth enamel, it is important to brush your teeth thoroughly during therapy..
  15. Due to taking an antibiotic, there may be false positive results when conducting a Coombs test and determining the level of glucose in urine.